Current Outbreak: Measles in the United States

The PGCoE network is actively monitoring the measles situation in the United States. To assist public health entities with quickly finding measles resources and identifying vetted protocols for sequencing measles, we have collated available information and protocols below. The wet laboratory protocols are established workflows in either public health or academic laboratories affiliated with PGCoE sites, and can be foundational resources for establishing in-house measles sequencing. We will continue to update this page as additional resources become available.

CDC and state dashboard links are provided for ease of access for those looking to gain situational awareness of the current measles virus outbreak status.

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Laboratory Protocols

Broad Institute Metagenomic Sequencing Protocol

Pooled metagenomics sequencing protocol (paired with hybrid capture using the Twist Comprehensive Viral Research Panel) that greatly decreases library preparation costs by allowing 24–96 samples to be processed through a single shared downstream reaction after reverse transcription.

Washington State Hybrid-Capture Measles Sequencing Protocol

Hybrid-catpure sequencing protocol using the Illumina Viral Surveillance Panel v2 for over 200 viral species, including the measle virus.

Situational Awareness

National Measles Cases and Outbreaks

CDC measles dashboard for tracking cases and outbreaks nationally.

APHL/CDC vaccine preventable diseases (VPD) dashboard for tracking VPD specimen submission to reference centers.

CSTE Measles Resource Guide

CSTE has developed a directory of trusted public health resources for clinical surveillance, communications, and laboratory response.

National Measles Wastewater Tracking

CDC measles wastewater dashboard for tracking the concentration of measles virus in wastewater nationally.

Arizona Measles Cases and Outbreaks

Arizona measles dashboard for tracking cases and outbreaks

Utah Measles Cases, Outbreaks, and Wastewater Concentration

Utah measles dashboard for tracking cases, outbreaks, and wastewater concentration.

South Carolina Measles Cases and Outbreaks

South Carolina measles dashboard for tracking cases and outbreaks

Michigan Measles Cases and Outbreaks

Michigan measles dashboard for tracking cases and outbreaks.

Virginia Measles Cases and Outbreaks

Virginia measles dashboard for tracking cases and outbreaks.